A genetic selection system for evolving enantioselectivity of enzymes.

A novel genetic selection system for improved enantioselectivity of Bacillus subtilis lipase A.

In directed evolution experiments, success often depends on the efficacy of screening or selection methods. Genetic selections have proven to be extremely valuable for evolving enzymes with improved catalytic activity, improved stability, or with altered substrate specificity. In contrast, enantioselectivity is a difficult parameter to select for. In this study, we present a successful strategy...

Enantioselective Extraction of Ofloxacin Enantiomers Using Ester Alcohol L-Tartarate as Chiral Selector

The distribution behavior of ofloxacin enantiomers was examined in the aqueous and organic solvent of a two-phase system containing chiral selector L-tartarate. The effect of extraction equilibrium time, buffer pH, organic solvents and length of alkyl chain of L-tartarate on the partition coefficients and enantioselectivity of racemic ofloxacin were investigated, respectively. The L-tartara...

An integrated environmental management approach to industrial site selection by genetic algorithm and fuzzy analytic hierarchy process in geographical information system

Environmental planning and management can have positive effects on development of some land uses including industrial areas that have a major effect on economic, social and environmental conditions. Considering the most important problems associated with modeling, the fundamental methods and functions of site-selection laid inside the geographical information system are not accounted for the mu...

Breeding Objectives and Desired-Gain Selection Index for Rayeni Cashmere Goat in Pasture System

The aim of this study was to define breeding goals and determine the suitable selection index in Rayeni cashmere goat using simulated data. To select animals for increased quantity of meat, milk and cashmere produced, body weight of the doe (BWD), milk weight (MW), cashmere weight (CW), weight of kids for sale (WK) and number of kids for sale per doe (NK) was used as selection criteria. Four se...

Cooperative Co-Evolving Neural Networks for Robosoccer Simulation